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KMID : 0988920220200020224
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Intestinal Research
2022 Volume.20 No. 2 p.224 ~ p.230
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Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease
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Weng Meng-Tzu
Shih I-Lun
Tung Chien-Chih
Leong Yew-Loong
Shieh Ming-Jium
Wang Cheng-Yi
Wong Jau-Min
Ni Yen-Hsuan
Wei Shu-Chen
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Abstract
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Background/Aims: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD.
Methods: This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively.
Results: In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679).
Conclusions: A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.
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KEYWORD
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Primary sclerosing cholangitis, Inflammatory bowel disease, Ulcerative colitis
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